医学编辑,Dr. Helen E. BURSTON


EDUCATION

Ph.D. in Medical Genetics

University of British Columbia

Vancouver BC, Canada

09/2005 – 07/2011


B.Sc. in Molecular Biology and Biochemistry (1st Class Honours)

Simon Fraser University

Vancouver BC, Canada

09/1999 - 09/2005

 

 

RESEARCH EXPERIENCE

 

 

1) Ph.D. student

Centre for Molecular Medicine and Therapeutics

Department of Medical Genetics, University of British Columbia

Vancouver BC, Canada

Supervisor: Dr. Elizabeth Conibear

09/2005 – 05/2011

 

Project description:  Genome-wide analysis of endocytic and vacuolar transport in S. cerevisiae.

 

2) Co-op Research Student

Merck Frosst

Department of Pharmacology

Kirkland QC, Canada

Supervisor: Dr. Stephanie Tuck

01/2004 - 01/2005

 

Project description: Development and characterization of pre-clinical mouse models of allergic asthma and COPD.

 

3) Honours Research Student

Simon Fraser University

Department of Molecular Biology and Biochemistry

Vancouver BC, Canada

Supervisor: Dr. Michel Leroux

05/2003 - 08/2003

 

Project description: Functional analysis of Bardet-Biedl proteins in C. elegans sensory cilia.

 

4) Co-op Research Student

BC Cancer Research

Department of Medical Biophysics

Vancouver BC, Canada

Supervisor: Dr. Andrew Minchinton

05/2002 - 12/2002

 

Project description: Evaluation of chemotherapy drug penetration in solid tumours.

 

 

5) Co-op Research Student

Simon Fraser University

Department of Biology

Vancouver BC, Canada

Supervisor: Dr. Zamir Punja

05/2001 - 08/2001

 

Project description: Explant regeneration of North American Ginseng in tissue culture.

 

 

AWARDS (RESEARCH)

 

1) Postgraduate Scholarship (PGS-D)

Natural Sciences and Engineering Research Council of Canada (NSERC)

05/2008 - 05/2010

 

2) Research Trainee Award

Michael Smith Foundation for Health Research (MSFHR)

04/2007 - 04/2008

 

3) Canada Graduate Scholarship (CGS-M)

Natural Sciences and Engineering Research Council of Canada (NSERC)

09/2005 - 08/2007

 

5) Student Research Award (USRA)

Natural Sciences and Engineering Research Council of Canada (NSERC)

05/2004 - 08/2004

 

AWARDS (ACADEMIC)

 

1) Graduate Entrance Scholarship

University of British Columbia

07/2005

 

 

 

PUBLICATIONS

 

Burston HE, Maldonado-Báez L, Davey M, Montpetit B, Schluter C, Wendland B, and Conibear E. (2009). Regulators of Yeast Endocytosis Identified by Systematic Quantitative Analysis. Journal of Cell Biology. 185(6):1097-110.

 

Burston HE, Davey M, Conibear E. (2008). Genome-wide Analysis of Membrane Transport Using Yeast Knockout Arrays. Methods in Molecular Biology, vol. Membrane Trafficking, ed. A. Vancura: Humana Press. 457:29-39.

 

Robichaud A, Tuck SA, Kargman S, Tam J, Wong E, Abramovitz M, Mortimer J, Burston HE, Masson P, Hirota J, Slipetz D, Kennedy B, O'Neill G, Xanthoudakis S. (2005). Gob-5 Is Not Essential for Mucus Overproduction in Preclinical Murine Models of Allergic Asthma. American Journal of Respiratory and Molecular Biology. 33:303-314.

 

Kyle AH, Huxham LA, Baker JH, Burston HE, Minchinton AI. (2003). Tumor distribution of bromodeoxyuridine-labeled cells is strongly dose dependent. Cancer Research. 63:5707-5711.

 

 PLATFORM AND INVITED PRESENTATIONS

 

 

 

 

 

Burston HE, Maldonaldo-Baez L, Montpetit B, Davey M, Schluter C, Wendland B, Conibear E. (2008). Genome-wide analysis of endocytic recycling (PhD work).

 

 

* Centre for Molecular Medicine and Therapeutics (CMMT) and Child & Family Research Institute (CFRI). (2009 and 2011: institutional seminar series).

 

* Yeast Genetics and Molecular Biology Meeting, University of Toronto, Ontario. Invited Platform Presentation. (2008: international conference).

 

* Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK. (2008: international invited oral presentation).

 

 

*Vancouver Area Yeast Meeting. Uncovering cellular sorting components by genome-wide phenotypic screening in S. cerevisiae. (2006 and 2008: provincial monthly meeting).

 

 

 

Burston, HE, Conibear, L. Uncovering the components and mechanisms of AP-3-mediated sorting by genome-wide phenotypic screening in S. cerevisiae. (PhD work)

 

 

*CFRI, 2006 Student Research Forum. (2006: Institutional)

 

 

 

 

 

POSTER PRESENTATIONS

 

 

 

Burston HE, Davey M, Raghuram N, and Conibear E. (2010). Regulation of Snc1 Recycling by the Alternate AP-1R Clathrin Adaptor and Ima1 (PhD work).

 

 

* Yeast Genetics and Molecular Biology Meeting, University of British Columbia, Vancouver BC. (2010: international conference).

 

 

 

Burston HE, Maldonaldo-Baez L, Montpetit B, Davey M, Schluter C, Wendland B, and Conibear E. (2008). Genome-wide analysis of endocytic recycling (PhD work).

 

 

* Excitatory Synapses & Brain Function, Gordon Research Conference.  Les Diablerets, Switzerland. (2009: international conference).

 

 

 

Burston, HE, Conibear, L. Uncovering the components and mechanisms of AP-3-mediated sorting by genome-wide phenotypic screening in S. cerevisiae. (PhD work)

 

*Biochemistry Research Day, University of British Columbia.  (2006: Annual institutional research day)

 

 

Contributions resulting from participation in industrially relevant R&D activities:

 

Merck Frosst, Canada. Student Research Day (Biochemistry/Pharmacology).  In-vivo siRNA utilization in preclinical murine models of allergic asthma. (2004: Institutional, undergraduate co-op work)

 

 

SUPERVISORY EXPERIENCE

 

Nandini Raghuram

Undergraduate Co-op Student

09/2008 - 06/2009 and 09/2010-present

 

Sarah Konefal

Undergraduate Co-op Student

01/2010 - 09/2010